I » Drugs and Pharmaceuticals Index

Drugs Index

Medical Conditions:

Drug Classes

Drugs Information:

Drugs List

Drugs RX » USA Drugs » I

iron sucrose injection

Generic Name: iron sucrose (injection) (EYE urn SOO krose)
Brand Names: Venofer

What is iron sucrose injection?

Iron sucrose is a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of oxygen in the blood.

Iron sucrose injection is used to treat iron deficiency anemia in people with kidney disease. It is usually given with another medication to promote the growth of red blood cells (such as Aranesp, Epogen, or Procrit).

This medication is not for treating other forms of anemia not caused by iron deficiency.

Iron sucrose injection may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about iron sucrose injection?

You should not receive this medication if you have ever had an allergic reaction to an iron injection, or if you have iron overload (the buildup of excess iron) or hemochromatosis.

Before you receive iron sucrose injection, tell your doctor if you have low blood pressure, hepatitis, or if you have received many blood transfusions in the past.

Iron sucrose injection can make it harder for your body to absorb iron medications you take by mouth. Tell your doctor if you are taking iron supplements or other iron-based oral medications.

What should I discuss with my healthcare provider before I receive iron sucrose injection?

You should not receive this medication if you have ever had an allergic reaction to an iron injection, or if you have iron overload (the buildup of excess iron) or hemochromatosis.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use iron sucrose injection:

low blood pressure;
hepatitis; or
if you have received many blood transfusions.

FDA pregnancy categor

Indocin Intravenous

Generic Name: indomethacin (Intravenous route)

in-doe-METH-a-sin

Commonly used brand name(s)

In the U.S.

Indocin

Available Dosage Forms:

Powder for Solution

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For Indocin

Indomethacin injection is used to treat patent ductus arteriosus (PDA) in premature infants (babies born too early) who weigh between 500 and 1750 grams. PDA is a heart problem where a blood vessel, the ductus arteriosus, fails to close normally after birth. This blood vessel is only used before birth, and is no longer needed after the baby is born. Indomethacin injection works by causing the PDA to constrict, and this closes the blood vessel. This medicine is used when other medical treatment for PDA fails after 48 hours.

This medicine is available only with your doctor's prescription.

Before Using Indocin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific probl

Imipenem and Cilastatin

Class: Carbapenems
Chemical Name: [5R - [5?,6?(R*)]] - 6 - (1 - Hydroxyethyl) - 3 - [[2 - (iminomethyl)amino]ethyl]thio] - 7 - oxo - 1 - azabicyclo[3.2.0]hept - 2 - ene - 2carboxylic acid monohydrate mixt. with [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl) carbonyl]amino]-2-heptenoic acid monosodium salt
Molecular Formula: C₁₂H₁₇N₃O₄S•H₂
CAS Number: 92309-29-0
Brands: Primaxin I.M.

Introduction

Antibacterial; fixed combination of imipenem (a carbapenem ?-lactam antibiotic)² ⁴ ⁵ ⁶ ¹⁴⁸ ¹⁹⁶ ¹⁹⁷ ¹⁹⁸ and cilastatin¹ ³⁵ (prevents renal metabolism of imipenem by dehydropeptidase I [DHP I]).¹ ² ¹⁰¹ ¹¹³ ¹²⁵ ¹³⁷ ¹⁴⁰ ¹⁴¹ ¹⁴⁵ ¹⁴⁸ ¹⁹⁶ ¹⁹⁸

Uses for Imipenem and Cilastatin

Bone and Joint Infections

Treament of serious bone and joint infections caused by susceptible Staphylococcus aureus (penicillinase-producing strains), S. epidermidis, Enterobacter, or Pseudomonas aeruginosa.¹ ¹⁴⁶ ¹⁶⁴

Imitrex Stat Dose Refill Subcutaneous

Generic Name: sumatriptan (Subcutaneous route)

soo-ma-TRIP-tan

Commonly used brand name(s)

In the U.S.

Alsuma
Imitrex
Imitrex Stat Dose Refill
Sumavel DosePro

Available Dosage Forms:

Kit
Solution

Therapeutic Class: Antimigraine

Pharmacologic Class: Serotonin Receptor Agonist, 5-HT1

Uses For Imitrex Stat Dose Refill

Sumatriptan injection is used to treat acute migraine attacks and cluster headaches in adults. It does not prevent migraine attacks nor treat certain types of migraine headaches (e.g., hemiplegic or basilar type).

Many people find that their headaches go away completely after they use sumatriptan. Other people find that their headaches are much less painful, and that they are able to go back to their normal activities even though their headaches are not completely gone. Sumatriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

Sumatriptan is not an ordinary pain reliever. It will not relieve any kind of pain other than migraine headaches. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Sumatriptan has caused serious side effects in some people, especially people who have heart or blood vessel disease. Be sure that you discuss with your doctor the risks of using this medicine as well as the good that it can do.

This medicine is available only with your doctor's prescription.

Before Using Imitrex Stat Dose Refill

Insulin Glulisine Vials

Pronunciation: IN-su-lin GLOO-lis-een
Generic Name: Insulin Glulisine
Brand Name: Apidra

Insulin Glulisine Vials are used for:

Treating diabetes mellitus. Insulin Glulisine Vials are usually used with a longer-acting insulin or insulin pump therapy.

Insulin Glulisine Vials are a fast-acting form of the hormone insulin. It works by helping your body use sugar properly. This lowers the amount of glucose in the blood, which helps to treat diabetes.

Do NOT use Insulin Glulisine Vials if:

you are allergic to any ingredient in Insulin Glulisine Vials
you are having an episode of low blood sugar

Contact your doctor or health care provider right away if any of these apply to you.

Before using Insulin Glulisine Vials:

Some medical conditions may interact with Insulin Glulisine Vials. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you drink alcoholic beverages or smoke
if you have kidney or liver problems; nerve problems; adrenal, pituitary, or thyroid problems; or diabetic ketoacidosis
if you use 3 or more insulin injections per day
if you are fasting, have high blood sodium levels, or are on a low-salt diet

Interferon Alfa

Class: Antineoplastic Agents
VA Class: AM800
Chemical Name: Interferon ?A (human leukocyte protein moiety reduced)
Molecular Formula: C₈₆₀H₁₃₅₃N₂₂₇O₂₅₅S₉C₈₆₀H₁₃₅₃N₂₂₉O₂₅₅S₉C₈₆₀H₁₃₅₃N₂₂₇O₂₅₅S₉
CAS Number: 76543-88-9
Brands: Intron A, Infergen, Alferon N

Systemically administered interferon alfa may cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders.^b ^c Patients should be closely monitored with periodic clinical and laboratory evaluations.^b ^c Discontinue therapy in patients with persistently severe or worsening signs or symptoms of these conditions.^b ^c In many, but not all cases, these disorders resolve after the drug is discontinued.^b ^c

REMS:

FDA approved a REMS for interferon alfa to ensure that the benefits of a drug outweigh the risks. However, FDA later rescinded REMS requirements. See the FDA REMS page () or the ASHP REMS Resource Center ().

Introduction

Interferon alfa is a family of homologous, species-specific proteins and, occasionally, glycoproteins with antiviral, antineoplastic, and immunomodulating activities.⁸ ⁴⁷ ⁵² ⁷⁰ ²⁵⁵ ²⁵⁹ ²⁶¹

Istodax

romidepsin
Dosage Form: injection
FULL PRESCRIBING INFORMATION

Indications and Usage for Istodax

Istodax is indicated for:

Treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.
Treatment of peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior therapy.

These indications are based on response rate. Clinical benefit such as improvement in overall survival has not been demonstrated.

Istodax Dosage and Administration

Dosing Information

The recommended dose of romidepsin is 14 mg/m2 administered intravenously over a 4-hour period on days 1, 8 and 15 of a 28-day cycle. Cycles should be repeated every 28 days provided that the patient continues to benefit from and tolerates the therapy.

Dose Modification

Nonhematologic toxicities except alopecia

Grade 2 or 3 toxicity: Treatment with romidepsin should be delayed until toxicity returns to ?Grade 1 or baseline, then therapy may be restarted at 14 mg/m2. If Grade 3 toxicity recurs, treatment with romidepsin should be delayed until toxicity returns to ?Grade 1 or baseline and the dose should be permanently reduced to 10 mg/m2.
Grade 4 toxicity: Treatment with romidepsin should be delayed until toxicity returns to ?Grade 1 or baseline, then the dose should be permanently reduced to 10 mg/m2.
Romidepsin should be discontinued if Grade 3 or 4 toxicities recur after dose reduction.

Hematologic toxicities

Grade 3 or 4 neutropenia or thrombocytopenia: Treatment with romidepsin should be delayed until the specific

Ibritumomab Tiuxetan with Indium-111

Pronunciation: EYE-bri-TOOM-oh-mab tye-UX-e-tan/IN-dee-um
Generic Name: Ibritumomab Tiuxetan with Indium-111
Brand Name: In-111 Zevalin

Rituximab, a medicine used along with Ibritumomab Tiuxetan with Indium-111, may cause serious, sometimes fatal side effects, such as difficulty breathing, lung problems, heart attack, irregular heartbeats, or shock. If these side effects occur, they usually occur with the first infusion within 30 minutes to 2 hours. Seek immediate medical attention if you develop trouble breathing, swelling, dizziness, lightheadedness, fainting, irregular heartbeat, chest pain, numbness of an arm or leg, sudden severe headache or vomiting, or sudden vision changes.

Ibritumomab Tiuxetan with Indium-111 causes severe and prolonged blood problems in most patients. Patients who have certain bone marrow problems should not use Ibritumomab Tiuxetan with Indium-111. If you develop unusual bruising or bleeding, fever, chills, sore throat, or other signs of infection, contact your doctor immediately.

Severe and sometimes fatal skin problems have been reported with use of Ibritumomab Tiuxetan with Indium-111. If you experience red, swollen, blistered, or peeling skin, contact your doctor immediately.

Ibritumomab Tiuxetan with Indium-111 is used for:

Treating non-Hodgkin lymphoma. It is used in combination with rituximab and 2 radioactive materials (In-111 and Y-90).

Ibritumomab is a monoclonal antibody protein. It works by binding to the cells that are involved in non-Hodgkin lymphoma. It is used along with 2 different radioactive materials. The first radioactive material (In-111) is attached to confirm that the cells are being reached. The second radioactive material (Y-90) is attached and damages the cells Ibritumomab Tiuxetan with Indium-111 binds to, which helps to reduce the number of abnormal cells

Isocaine

mepivacaine hydrochloride
Dosage Form: injection, solution
Mepivacaine HCl 3%
(Mepivacaine Hydrochloride Injection, USP)

Mepivacaine HCl 2%
(with Levonordefrin 1:20,000)
(Mepivacaine Hydrochloride and Levonordefrin Injection, USP)

Rx Only

THESE SOLUTIONS ARE INTENDED FOR DENTAL USE ONLY.

Isocaine Description

Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula:

It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.

Levonordefrin, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solution, is (-)-

It is a white or buff-colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water;
DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.

Mepivacaine hydrochloride injection 3% and Mepivacaine hydrochloride 2% with levonordefrin 1:20,000 injection are sterile solutions for injection.

COMPOSITION

	CARTRIDGE
Each mL contains:	2%	3%
Mepivacaine Hydrochloride	20 mg

Influenza Virus Vaccine Live Intranasal

Class: Vaccines
VA Class: IM100
Brands: FluMist

Introduction

Live, attenuated virus vaccine.¹ ¹⁰⁰ Seasonal influenza virus vaccine live intranasal is a trivalent vaccine containing live (cold-adapted) influenza virus types A and B and is used to stimulate active immunity to influenza virus strains contained in the vaccine.¹ ¹⁰⁰

Uses for Influenza Virus Vaccine Live Intranasal

Prevention of Seasonal Influenza A and B Virus Infections

Prevention of seasonal influenza virus infection in children ?2 years of age, adolescents, and adults 18 through 49 years of age.¹ ¹⁰⁰ ²⁰⁰

Influenza is an acute viral infection; influenza viruses spread from person to person mainly through large-particle respiratory droplet transmission.¹⁰⁰ In the US, epidemics of seasonal influenza occur annually, usually during late fall through early spring.¹⁰⁰ Influenza viruses can cause illness in any age group; children have highest rate of infection.¹⁰⁰ Influenza can exacerbate underlying medical conditions or lead to pneumonia in certain individuals.¹⁰⁰ Individuals ?65 years of age, children <2 years of age, and individuals with chronic medical conditions have highest risk of influenza-related complications and death.¹⁰⁰

Annual vaccination is the most effective strategy for preventing seasonal influenza and its complications.¹⁰⁰

Beginning in the 2010–2011 influenza season, the US Public Health Service Advisory Committee o

Iprivask

Pronunciation: DES-i-ROO-din
Generic Name: Desirudin
Brand Name: Iprivask

Tell your doctor you use Iprivask before you have any type of spinal puncture or epidural/spinal anesthesia. Patients who have these procedures while they use Iprivask are at risk of developing a blood clot on or near the spinal cord. This could result in long-term or permanent paralysis.

The risk is increased in patients who have an indwelling epidural catheter, traumatic or repeated epidural or spinal puncture, or a history of a deformed spine or spinal surgery, and in patients who use medicines that may affect blood clotting, such as warfarin, aspirin, platelet inhibitors (eg, clopidogrel), and nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen).

If you have a spinal puncture or epidural/spinal anesthesia while you use Iprivask, tell your doctor right away if you notice any signs or symptoms of nerve problems, such as numbness or tingling, muscle weakness, or paralysis.

Iprivask is used for:

Preventing blood clots in patients having hip replacement surgery. It may also be used for other conditions as determined by your doctor.

Iprivask is a thrombin inhibitor. It works by blocking the activity of thrombin, which helps to prevent the formation of blood clots.

Do NOT use Iprivask if:

you are allergic to any ingredient in Iprivask or to another hirudin (eg, lepirudin)
you have active major bleeding or bleeding problems that cannot be stopped

Contact your doctor or health care provider right away if any of these apply to you.

Before using Iprivask:

Some medical conditions may interact with Iprivask. Tell your doctor or pharmacist if you

infliximab

Generic Name: infliximab (in FLIX ih mab)
Brand Names: Remicade

What is infliximab?

Infliximab reduces the effects of a substance in the body that can cause inflammation.

Infliximab is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. Infliximab is also used to treat severe or disabling plaque psoriasis (raised, silvery flaking of the skin).

Infliximab is often used when other medicines have not been effective.

Infliximab may also be used for purposes not listed in this medication guide.

What is the most important information I should know about infliximab?

You should not use this medication if you are allergic to infliximab, or if you are also being treated with anakinra (Kineret) or abatacept (Orencia). Some people using infliximab have developed a rare fast-growing type of lymphoma (cancer). This condition affects the liver, spleen, and bone marrow, and it can be fatal. This has occurred mainly in teenagers and young adults using infliximab or similar medicines to treat Crohn's disease or ulcerative colitis. Call your doctor at once if you have any of the following symptoms: fever, night sweats, itching, loss of appetite, weight loss, tiredness, feeling full after eating only a small amount, pain in your upper stomach that may spread to your shoulder, nausea, easy bruising or bleeding, pale skin, feeling light-headed or short of breath, rapid heart rate, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Infliximab can lower blood cells that help your body fight infections. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Serious and sometimes fatal infections may occur during treatment with infliximab. Contact your doctor right

isometheptene, dichloralphenazone, and acetaminophen

eye-soe-meth-EP-teen MUE-kate, dye-klor-al-FEN-a-zone, a-seet-a-MIN-oh-fen

Commonly used brand name(s)

In the U.S.

Amidrine
Diacetazone
Duradrin
Epidrin
Iso-Acetazone
Midrin
Migquin
Migratine
Migrazone
Migrin-A
Nodolor
Va-Zone

Available Dosage Forms:

Capsule

Therapeutic Class: Acetaminophen Combination

Pharmacologic Class: Isometheptene

Uses For isometheptene, dichloralphenazone, and acetaminophen

Isometheptene, dichloralphenazone, and acetaminophen combination is used to treat certain kinds of headaches, such as “tension” headaches and migraine headaches. This combination is not used regularly (for example, every day) to prevent headaches. It should be taken only after headache pain begins, or after a warning sign that a migraine is coming appears. Isometheptene helps to relieve throbbing headaches, but it is not an ordinary pain reliever. Dichloralphenazone helps you to relax, and acetaminophen relieves pain.

isometheptene, dichloralphenazone, and acetaminophen is available only with your doctor's prescription.

Before Using isometheptene, dichloralphenazone, and acetaminophen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For isometheptene, dichloralphenazone, and acetaminophen, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to isometheptene, dichloralphenazone, and acetaminophen or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or p

Infergen

Pronunciation: IN-ter-FEER-on AL-fa-kon-1
Generic Name: Interferon Alfacon-1
Brand Name: Infergen

Infergen may cause or aggravate fatal or life-threatening autoimmune (eg, lupus), neuropsychiatric (eg, depression), ischemic (eg, heart problems), or infectious disorders. Contact your health care provider if persistent or worsening symptoms of these conditions occur.

Infergen is used for:

Treating long-term hepatitis C virus infection in patients 18 years of age or older. It may also be used for other conditions as determined by your doctor.

Infergen is an interferon. Exactly how interferon alfacon-1 works against the hepatitis C virus is not known. It may directly kill the virus, prevent the virus from reproducing, or alter the body's natural defense against the virus.

Do NOT use Infergen if:

you are allergic to any ingredient in Infergen or products taken from Escherichia coli
you are pregnant, planning to become pregnant, or are breast-feeding
you have autoimmune hepatitis (inflammation of the liver) or severe or worsening liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Infergen:

Some medical conditions may interact with Infergen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

Iron/Vitamin C/Folic Acid

Pronunciation: EYE-urn/VYE-ta-min C/FOE-lik AS-id
Generic Name: Iron/Vitamin C/Folic Acid
Brand Name: NovaFerrum

Accidental overdose of products that contain iron is a leading cause of fatal poisoning in children younger than 6 years old. Keep this and all medicines out of the reach of children. In case of accidental ingestion, call the poison control center or a doctor at once.

Iron/Vitamin C/Folic Acid is used for:

Preventing and treating anemia caused by low levels of iron in the body (iron deficiency anemia). It may also be used for other conditions as determined by your doctor.

Iron/Vitamin C/Folic Acid is a vitamin, iron, and folic acid combination. It works by providing vitamins, iron, and folic acid to the body to help meet nutritional requirements.

Do NOT use Iron/Vitamin C/Folic Acid if:

you are allergic to any ingredient in Iron/Vitamin C/Folic Acid
you have high levels of iron in your body (eg, hemosiderosis, hemochromatosis) or you have a certain type of anemia (hemolytic anemia)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Iron/Vitamin C/Folic Acid:

Some medical conditions may interact with Iron/Vitamin C/Folic Acid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medi

Ibandronate

Pronunciation: eye-BAN-droe-nate
Generic Name: Ibandronate
Brand Name: Boniva

Ibandronate is used for:

Treating osteoporosis (weak bones) in women who are past menopause.It may also be used for other conditions as determined by your doctor.

Ibandronate is a bisphosphonate. It works by slowing bone loss and allowing new bone to be formed.

Do NOT use Ibandronate if:

you are allergic to any ingredient in Ibandronate
you have severe kidney problems or low levels of calcium in your blood

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ibandronate:

Some medical conditions may interact with Ibandronate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have cancer, anemia, or blood clotting problems, kidney problems, or if you have an infection
if you have low blood calcium levels, low blood vitamin D levels, or you are unable to take calcium or vitamin D supplements
if you have poor dental hygiene or other dental problems, or an upcoming dental procedure
if you have had or will be having chemotherapy or radiation treatment

Some MEDICINES MAY INTERACT with Iba

Iodoflex Topical

Generic Name: iodine (Topical route)

EYE-oh-dine

Commonly used brand name(s)

In the U.S.

Aplicare One Tincture Of Iodine
Iodex
Iodoflex
Iodosorb

Available Dosage Forms:

Swab
Ointment
Tincture
Dressing
Gel/Jelly

Therapeutic Class: Antibacterial

Uses For Iodoflex

Topical iodine is used to prevent and treat infections that may occur in minor scrapes and cuts. It works by killing bacteria that can cause infections.

Before Using Iodoflex

Allergies

Pediatric

Use of topical iodine is not recommended for newborn infants because it may cause skin and thyroid problems.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of topical iodine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interac

Invanz

Generic Name: ertapenem (Injection route)

er-ta-PEN-em

Commonly used brand name(s)

In the U.S.

Invanz

Available Dosage Forms:

Powder for Solution

Therapeutic Class: Antibiotic

Pharmacologic Class: Beta-Lactam

Chemical Class: Carbapenem

Uses For Invanz

Ertapenem is used alone or in combination with other antibiotics to treat infections caused by bacteria in many different parts of the body. It works by killing bacteria or preventing their growth. This medicine will not work for colds, flu, or other virus infections. Ertapenem is also used to prevent infections after having surgery of the colon and rectum .

This medicine is available only with your doctor's prescription.

Before Using Invanz

Allergies

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of ertapenem in infants and children 3 months to 17 years of age. Use in infants younger than 3 months of age is not recommended .

Geriatr

Increlex

Generic Name: mecasermin (ME ka SER min)
Brand Names: Increlex

What is mecasermin?

Mecasermin is a man-made form of insulin-like growth factor-1 (IGF-1), a substance that is normally produced in the body. IGF-1 is important for the growth of bones and muscles.

Mecasermin is used to treat growth failure in children whose bodies do not make enough IGF-1.

Mecasermin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about mecasermin?

Your child should not use this medication if he or she is allergic to mecasermin, or if the child has cancer or has finished growing and his or her bone growth plates are closed. Mecasermin is not for use in children who have growth hormone deficiency, malnutrition, underactive thyroid, or those who are taking long-term steroid medications.

Before your child receives mecasermin, tell the doctor if your child has diabetes, kidney disease, liver disease, a curved spine (scoliosis), or if the child has ever had an allergic reaction to a preservative called benzyl alcohol.

Mecasermin is injected under the skin. You and your child may be shown how to use injections at home. Make sure you fully understand how to give the injection and properly dispose of used needles and syringes.

Do not give this medication as an IV injection directly into a vein. Use a different place on your child's upper arm, thigh, stomach, or buttocks each time you give your child a mecasermin injection. Give the mecasermin injection 20 minutes before or after the child eats a meal or snack. Skip the dose if the child's meal or snack will be missed. Mecasermin can cause low blood sugar, which may be worse if the child does not eat before or after the injection. Call your doctor at once if your child has a serious side effect such as blurred vision, headache o

Isosorbide

Dosage Form: tablet, extended release
Isosorbide Dinitrate Extended-Release Tablets, USP
40 mg

Rx only

DESCRIPTION

Isosorbide dinitrate (ISDN), an organic nitrate, is a vasodilator with effects on both arteries and veins. Isosorbide dinitrate is available as 40 mg extended release tablets. The chemical name for Isosorbide dinitrate is 1,4: 3,6- dianhydro- D- glucitol 2, 5- dinitrate, an organic nitrate whose structural formula is

and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents, such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Each Isosorbide dinitrate extended relase tablet, USP, for oral administration, contains 40 mg of Isosorbide dinitrate, in a matrix that causes the active drug to be released over a sustained period. In addition, each tablet also contains the following inactive ingredients: colloidal silicon dioxide, hypromellose, lactose monohydrate and magnesium stearate.

Conformance of Isosorbide dinitrate extended release tablets with USP release test is pending.

CLINICAL PHARMACOLOGY

The principal pharmacological action of Isosorbide dinitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reduci